New high resistance QPlates & complete HiR consumables range: A breakthrough in electrophysiology for automated patch clamping of organelles and small cells
Sophion Bioscience introduces new QPlates HiR, offering a comprehensive range of high resistance consumables, designed for precise electrophysiological subcellular recordings on organelles and small cells. With smaller hole diameters, our HiR consumables help you improve giga-ohm seal formation, achieve higher success rates, and deliver more consistent and reliable data. This breakthrough technology marks a significant advancement in the accessibility, reliability, and throughput of automated electrophysiology for organelles and small cells.
Optimize your ion channel research in organelles and small cells with Sophion high resistance consumables
Whether you prefer flexible, hands-on control or high throughput, fully automated walk-away operation, we offer platforms to match your needs. Combined with our comprehensive range of high resistance consumables, our instruments are purpose-built to support ion channel research in organelles and small cells. Our platforms, QPatch Compact, QPatch, and Qube 384, enable streamlined, automated workflows with optimized, ready-to-use assay protocols – ideal for efficient and reliable subcellular ion channel research. You can even run your experiments without seal enhancers, helping to preserve native cell physiology and avoid unwanted alterations. Let us help you find the right fit for your workflow and research goals in organelles and small cells.
3 Powerful platforms & advantages of choosing Sophion
QPatch Compact: Flexible automated recording of organelles and small cells
- Greater control over complex or novel cell types
QPatch Compact offers hands-on control over key steps like cell placement and recording initiation. This is ideal for method development or low-yield organelles and small cells. - Flexible protocol design for specialized assays
You can easily adjust experimental parameters and workflows, making it ideal for custom protocols that may be required for organelle-specific or small cell ion channel research. - Cost-efficient solution & careful use of limited or precious samples
The system enables precise gigaseal recordings of up to 8 organelles or small cells simultaneously, with careful manual optimization that preserves rare cellular material like mitochondria or iPSC neurons.
QPatch: Fully automated patch clamp solution for organelles and small cells in physiological conditions
- High success rates with fragile organelles and small cells
Our QPatch platform is optimized to handle delicate organelles and small cells without the need for seal enhancers, preserving cell integrity and delivering consistent success rates of around 65% for reliable, high-quality data. - Scalable data generation for rare or limited cellular material
The high throughput platform allows precise parallel gigaseal recordings of up to 16 or 48 organelles and small cells, ideal for high-quality ion channel studies of rare hard-to-isolate organelles or challenging small cells like red blood cells. - Minimized variability and user bias
Automation ensures consistent handling and assay conditions, which can be critical when working with organelles or small cells that are highly sensitive to experimental variation.
Qube 384: Maximum throughput automated patch clamp solution for organelles and small cells
- Highest throughput and cost-saving electrophysiology solution for organelles and small cells
Our Qube platform is optimized for efficient, high-precision parallel gigaseal recordings on 384 organelles and small cells – ideal for testing thousands of compounds and significantly reducing the overall cost of drug screening. - Broader research scope and complex experiment capabilities
The Qube 384 enables experiments on many organelles and small cells in parallel, allowing the study of multiple ion channel types, conditions, or compounds in less time. This enables you to expand the scope of your research and supports high-impact studies. - Fully automated, true walk-away solution with up to 8 hours of unattended operation
With Qube’s true walk-away operation, you can maximize lab efficiency, save valuable time, and meet tight deadlines—while maintaining consistent success rates of around 50% when patching organelles and small cells.
Interested in learning more about our new high-resistance QPlates and complete HiR consumables range – and how they can enhance your research?
We offer a broad range of platforms – from highly flexible, user-controlled systems to high throughput automated patch clamp solutions – each tailored to your specific research needs. Talk with our experts for an in-depth introduction to our technologies and let us help you find the ideal solution for your ion channel research. Discover more – book a meeting with one of our experts today.